Addyi

Addyi

Addyi is the only drug that is approved for the treatment of female sexual dysfunction.

Addyi has been specifically designed for women, who suffer from low sexual desire and want to increase their libido.

Even before the start of Addyi sales, this drug became known as the “Female Viagra”. However, Addyi and Viagra are completely different drugs with different active ingredients and different action mechanism.

Addyi tablets contain the active ingredient Flibanserin. This ingredient helps strengthen the sexual desire by activating sexual stimuli in the brain.

Because Flibanserin enhances the brain’s response to erotic stimuli, it helps women:

  • Increase sexual desire
  • Increase the frequency of sexual intercourse.

Addyi tablets (Flibanserin) are recommended only to women, who are experiencing serious stress and discomfort due to the low frequency of sexual intercourses. Addyi pills are not prescribed to women, who are satisfied with their sexual relationship.

For a significant increase in libido, Addyi must be taken every day. Clinical studies have shown that regular use of Addyi increases the frequency of intercourse by about 50%.

Despite the proven efficacy, Addyi tablets failed to repeat the success of the first pill to treat male sexual dysfunction Viagra.

Manufacturer of Addyi tablets claims that every 10 women in the US suffer from low sexual desire.

However, in the first two months after the start of Addyi sales, no more than 1000 prescriptions for this drug were issued.

Low popularity of Addyi tablets results from a combination of several factors that include high treatment cost.

Price per Addyi dose is about $ 25. Viagra pills for men have about the same price. Yet, unlike Viagra pills for men that are used “as needed”, Addyi pills must be taken on a daily basis.

When buying Addyi without insurance, the cost of one-month treatment for female sexual dysfunction will amount to more than $ 750. Most women consider such cost unreasonably high, and try to find more affordable methods to increase libido.

Addyi tablets

Addyi: how to recognize the original “female Viagra”.

Today Addyi is the only drug for treatment of hypoactive disorders of sexual desire in women. Addyi is produced in the form of oral tablets that possess some distinctive features, including:

  • Addyioval shape
  • marking “100” on one side
  • pale pink film coating.

Addyi pills for increase of female libido are available in vials. A vial includes 30 original tablets; each contains 100 mg of Flibanserin.

In addition to the active substance, Addyi tablets include excipients. Due to these inactive ingredients, Addyi tablets have high durability and storage stability. Furthermore, these excipients promote dissolution of Addyi tablets after oral administration.

Today Addyi pills are sold only in the USA. They are manufactured by Valeant company. You can order Addyi pills from Australia on online pharmacy.

Addyi contraindications

A full list of Addyi contraindications.

Addyi tablets have a very small list of contraindications. Addyi is intended to treat hypoactive sexual desire disorder only in premenopausal women, and not intended for:

  • Addyi 100mgmen
  • children and adolescents
  • postmenopausal women.

In addition, Addyi tablets are contraindicated in patients with liver disease or a history of alcohol dependence. Use of Addyi is not recommended for women during:

  • pregnancy
  • breastfeeding.

Addyi is metabolized under the influence of CYP3A4. In deficiency of this cytochrome, Addyi concentration in the blood plasma increases that can cause fainting or sudden drop in blood pressure.
To avoid these side effects, Addyi is contraindicated to take together with drugs inhibiting the synthesis of CYP3A4 cytochrome in the body, such as:

  • Cimetidine
  • Resveratrol
  • Posaconazole
  • Telithromycin.

In addition, Addyi can interact with alcohol. In this regard, Addyi tablets are contraindicated to take during alcohol intoxication and together with products that contain alcohol (drinks or infusions).

Addyi dosage

Dosing regimen of Addyi 100 mg.

The only optimal dose of Addyi approved for treatment of female hypoactive sexual disorder is 100 mg per day. To increase libido, Addyi 100 mg should be taken by patients whose sexual dysfunction caused by:

  • Addyipremenopause
  • severe stress
  • low self-esteem
  • mental Illnesses.

For the safest and the most effective treatment of lack of libido, women should observe the recommended dosing regimen of Addyi:

  • To restore and increase sexual desire, women are advised to take an Addyi 100 mg tablet per day.
  • To prevent a sharp decline in blood pressure or appearance of daytime sleepiness, Addyi tablets should be taken to a maximum of 6 hours prior to bedtime.

If you miss an evening dose of Addyi 100 mg, do not take it the next morning and do not double the next dose.

Just skip the missed dose of Addyi 100 mg and continue to use this medication in accordance with the prescribed regimen.

Use of Addyi 100 mg should be discontinued if woman still experiences lack of sexual desire after two months of medical treatment.

Addyi side effects

How to avoid Addyi adverse reactions.

The results of clinical studies of Addyi confirm that this drug for treatment of female hypoactive sexual desire disorder may cause adverse reactions very rare.

The most common adverse reactions of Addyi that occurred in women during laboratory studies of this drug are:

  • nausea
  • fatigue
  • dry mouth
  • dizziness
  • difficulty falling asleep.

Drinking alcohol while using Addyi significantly increases risk of such adverse reactions as:

  • fainting
  • hypotension.

In addition, these adverse reactions may occur in women in simultaneous use of Addyi with:

  • antibiotics (Ciprofloxacin)
  • antidepressants (Conivaptan)
  • antifungal (Itraconazole)
  • antihypertensive drugs (Diltiazem)
  • medicines for treatment of HIV-1 infection (Ritonavir).

TheseAddyi side effects do not dependent on the dose, but quickly go away in furtheruse of this drug. Addyi may cause drowsiness, so these pills should be taken only in the evening or just before bedtime.

Addyi pros and cons

Addyi is used to treat generalized hypoactive sexual desire disorder (HSDD) in women, which manifests itself in a lack of interest in sexual activity. The medicine enhances sexual desire in women and aids the elimination of difficulties in interpersonal relationships. Just like any medication, Addyi has its advantages and disadvantages.

Advantages of Addyi

The medicine has a minimum dosing frequency. To increase sexual desire, it is enough for a woman to take one Addyi tablet in before bedtime.

A single dose of Addyi promotes:

  • improvement in blood circulation and increased sensitivity of the vagina;
  • increased production of vaginal secretion, thereby enhancing the orgasm;
  • restoration of the disturbed neurotransmitters balance, which promote the appearance of sexual attraction.

The results of clinical studies have demonstrated that the vast majority of women have experienced sexual desire after taking Addyi. The medicine allows women to initiate sexual relations by themselves.

Disadvantages of Addyi

Addyi shortcomings that should be noted include the time of the drug administration – only at night. Use of the drug in the morning or afternoon significantly increases the risk of side effects (blood pressure lowering, fainting, drowsiness). Thus, spontaneous sexual activity is practically impossible during the use of Addyi.

Addyi enhances the natural sexual desire in women.

However, the drug will be ineffective, if the problems in sexual life are caused by:

  • influence of drugs
  • difficulties in interpersonal relationships
  • chronic diseases or other health problems.

Addyi has no proven effectiveness for HSDD treatment. Its use in gynecological practice is based only on the results of clinical trials. But the exact mechanism of the drug action is still unknown. Clinical experts suggest that Addyi increases the impact of serotonin, norepinephrine and dopamine over the prefrontal cortex.

There is no clinical evidence that Addyi significantly increases sexual desire in women. Sexual desire is a more complex and amorphous state, than sexual arousal. Therefore, the physiological aspects of sexual desire are subject to further study.

Addyi Flibanserin

What should you know about Addyi?

Addyi is an alternative brand name of the only drug to date – Flibanserin for treatment of disorder of sexual desire in women. In the United States and other countries of the world, Addyi is often called “Viagra for women.”

Addyi is available as pink oval shaped tablets that contain 100 mg of active ingredient Flibanserin.

Addyi tablets are prescribed for adult women to:

  • increase sexual desire
  • prevent stress in premenopausal
  • provide adequate sexual behavior.

Addyi affects the central regions of the woman’s brain by regulating the balance of dopamine, norepinephrine and serotonin.

Thus, Addyi helps restore sexual desire in a woman with sexual dysfunction.

Addyi is not intended to treat a weak sexual desire in men or adolescents under 18 years.

In addition, Addyi pills are not prescribed to women who experience insufficient sexual desire because of:

  • endocrine diseases
  • effect of hormonal medications
  • complications in relationship with the partner
  • neurological or psychological disorders.

The manufacturer of Addyi tablets is Sprout Pharmaceuticals. In 2015, this company became a part of Valeant Corporation and transferred it all rights for further production and supply of Addyi on the world market.

Addyi tablets were approved by the FDA for use in the USA in 2015, but they have not been yet authorized in the EMA. Today, Europeans can order Addyi only on online pharmacy.

Facts and figures about the history of Addyi creation

Addyi tablets were developed by Boehringer Ingelheim Company.

In 2008, this company tried to obtain a marketing authorization for Addyi in Europe, and in 2010 in the United States. After the FDA refused to approve Addyi for the treatment of female sexual dysfunction, Boehringer Ingelheim announced the termination of this drug investigations.

In 2012, the rights to Addyi were acquired by Sprout Pharmaceuticals. This company managed to conduct successful clinical trials and prove that Addyi benefits outweigh its potential risks.

In 2015, Sprout Pharmaceuticals acquired the rights to commercialize Addyi in the United States. However, only 2 days after the FDA approved Addyi to increase libido in women, Sprout Pharma sold all rights to the drug company Valeant Pharmaceuticals.

Today, Valeant owns exclusive rights for Addyi worldwide.

In 2017, Addyi pills are sold only in the US, yet these pills to enhance sexual desire may be on sale in Australia in the next year.

If you are looking for the best drug to increase libido in women, you can find detailed information about Addyi into the leaflet for consumers and professionals.

Before you buy Addyi, learn more about the first drug for the treatment of female sexual dysfunction, and discuss the pros and cons with your doctor.