Medications that cause erectile dysfunction

Medications ED

The use of drugs is one of the most common risk factors for erectile dysfunction. The list of drugs that cause erectile dysfunction (ED) includes antihistamines, antihypertensives, opioid analgesics, antiandrogenic, antipsychotics and antidepressants.

The results of clinical studies confirm that antihypertensives of the old generation can cause male potency violation. The list of the most common antihypertensive drugs that cause ED includes:

  • β-blockers – Verapamil (Anpec)
  • Antiarrhythmic drugs – Digoxin (Lanoxin)
  • Vasodilators – Methyldopa (Aldomet), Clonidine (Catapres)
  • Diuretics – Indapamide (Napamide), Spironolactone (Aldactone).

These antihypertensives help reduce the lumen in the penile artery, which can cause a violation of blood circulation in the penis. New-generation antihypertensives, such as Nebivolol (Nebilet), do not have a negative impact on male reproductive health.

The mechanism of the ED development with the use of antiandrogens is associated with their property of reducing the synthesis of male hormones. Testosterone deficiency, caused by antiandrogens, increases the risk of atrophy of the cavernous nerves, which can lead to a potency disorder.

Such drugs as Cyproterone acetate (Cyprone), Ketoconazole (Daktagold) or Cimetidine (Magicul), have a high antiandrogenic activity, and can cause ED. In most cases, men retain the ability to get an erection during the course of antiandrogens.

Prolonged use of opioid analgesics is also a risk factor for imbalance of hormones, and can cause endocrine ED. Violations of potency can be caused by such opioid analgesics, as

  • Oxymorphone (Opana)

  • Methadone (Aspen)

  • Morphine (Kadian).

Violation of sexual function in men is one of the common side effects of antipsychotics and antidepressants, in particular selective serotonin reuptake inhibitors (SSRI).

  • The most popular antipsychotics that cause ED are Olanzapine (Zyprexa), Quetiapine (Seroquel), and Aripiprazole (Abilify);

  • Violation of potency can be caused by such antidepressants, as Mirtazapine (Axit), Bupropion (Zyban) or Venlafaxine (Efexor).

These drugs have a direct effect on the central nervous system. In particular, they reduce the activity of serotonin and dopamine receptors, which play an important role in the mechanism of erection.

Other drugs that suppress CNS activity and can cause temporary ED are antihistamines: Diphenhydramine (Panadol), Cimetidine (Magicul), Promethazine (Phenergan), Ranitidine (Zantac), and Nizatidine (Nizac).

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