Uprima

Uprima is the drug for the treatment of erectile dysfunction (erectile dysfunction), which were available on sale in Europe for several years.

Supplier of Uprima tablets was the company Abbott Laboratories.

The company received a centralized European authorization for Uprima tablets in 2001. In just 5 years after the start of sales, Abbott has refused to extend the European authorization for Uprima, and this drug was withdrawn from the market.

  • In the period of 2001 to 2005, Uprima tablets of 2mg and 3mg were sold in Europe.
  • Another Uprima dose of 4mg was available on the international market.

In 2002, the cost of one 3mg Uprima tablet was approximately 10 euro. For comparison, Viagra 100mg was sold in 2002 at a price of about 12 euro per pill.

Despite the relatively low cost of Uprima tablets, Abbott company failed to make them a bestseller. A key reason for the unsuccessful launch of Uprima sales was their low efficiency.

Abbott voluntarily recalled Uprima drug from the European market, and, thus, admitted the defeat in the competition with the manufacturer of Viagra tablets.

Medical experts agree that the benefits of Uprima drug exceed its potential risks. However, they were not prescribing Uprima, and continued to prescribe more effective pills for the treatment of erectile dysfunction, Viagra.

Uprima drug had several distinctive features that made it differ from any other drug for the erectile dysfunction treatment.

The first difference – pharmaceutical form and presentation.

  • Uprima drug was produced in the form of sublingual tablets that dissolve in the mouth within a few seconds. In the early 2000’s, Uprima were the only orally dispersible tablets for the treatment of erectile dysfunction.

The second difference – fast effect.

  • Uprima tablets help restore an erection within 10-20 minutes after their intake (on average 18-19 minutes). Viagra tablets start working 30-60 minutes after the ingestion.

The third difference – the action mechanism.

  • Uprima helped achieve and maintain an erection by influencing the central nervous system. Viagra helps restore the ability to sexual activity by strengthening the blood flow to the penis.

The fourth difference – the effect duration.

  • The average duration of Uprima effect was approximately 2 hours. Viagra pills work at least 4 hours after the intake.

If we evaluate the efficiency of Uprima by the results of clinical trials, we can include it in the list of 10 best products for the treatment of erectile dysfunction.

However, the analyses of post-marketing study results brought the opposite conclusion. As it turned out, every second man, who was taking an Uprima dose of 2 mg or 3 mg was not able to achieve and maintain an erection sufficient for a successful sexual intercourse.

By increasing the dose of Uprima to 5 mg or 6 mg, the number of successful intercourse increased. At that, the frequency and severity of side effects also increased. Therefore, Uprima doses above 3mg were prescribed very rarely.

After numerous negative reviews about Uprima, doctors stopped prescribing this drug to men, and its sales began to decline in a fast pace. Gradually, Uprima tablets disappeared from the shelves of pharmacies, and today only health professionals remember about this drug.

Uprima tablets

Buy Uprima tablets for solving sexual problems.

After intake of Uprima sublingual tablets, active ingredient Apomorphine rapidly reaches the maximum concentration in the blood plasma. Since the drug substance penetrates immediately into the bloodstream, stable erection occurs 20 minutes after the tablet.

The owner of a marketing authorization for Uprima is a pharmaceutical company Abbott. Blister packs contain two and four tablets of brick-red color with Abbott logo on one side.

uprimaDepending on a dose of the active ingredient, the tablets had different shapes and different markings:

  • Uprima 2 mg – pentagonal tablets marked with “2”
  • Uprima 3 mg – triangle tablets marked with “3”.

On May 28, 2006, after expiration of the marketing authorization, Abbott company decided to stop selling this drug in Europe. Sales of Uprima tablets were discontinued because the drug has not withstood competition on the pharmaceutical market with Cialis, Viagra and other drugs for erectile dysfunction.

Uprima dosage

How to choose Uprima dose properly.

To restore sexual function, men should take Uprima sublingual tablets about 20 minutes before planned sexual activity. For patients with erectile dysfunction, there are several approved doses of Uprima that make:

  • 2 mg per day – the minimum therapeutic dose;
  • 3 mg in 24 hours – the average optimal dose;
  • 9 mg split into three intakes per day – the maximum dose.

At the beginning of erectile dysfunction therapy, patients should take the minimum daily dose of Uprima 2 mg per day. If low penile rigidity persists after two attempts of using this dose of Uprima, the next dose can be increased to 3 mg.

The minimal dose of Uprima 2 mg daily is recommended to take to reduce risk of drug interaction or adverse reactions in:

  • Moderate liver disease
  • Simultaneous use of nitrates (nitroglycerin).

The minimum time interval between Uprima doses makes 8 hours. Sexual stimulation is needed for occurrence of a full erection after sublingual administration of optimal dose of Uprima 2 or of 3 mg.

The maximum dose of Uprima 9 mg per day is the most effective. However, because of high risk of adverse reactions, this dose of Uprima is not intended for constant use.

Uprima 2 mg

Uprima 2 mg sublingual tablets.

For some years (2001 to 2006), Uprima drug was used to solve problems with sexual dysfunction. 2 mg – is the maximum dose of the drug, which elderly patients could take.

An interval between intakes of two Uprima 2 mg tablets should be at least 8 hours for people over 65 years of age. Since active ingredient Apomorphine is excreted by the kidneys, men with severe renal impairment should not take more than Uprima 2 mg per day.

Since the drug is metabolized mainly in the liver, half-life of the drug is increased in patients with liver failure.

Men with impaired hepatic function should start treatment with Uprima 2 mg per day. Any increase in the dose up to 3 mg was carried out considering the risk benefit ratio individually for each patient and in constant control of hepatic function.

Uprima 2 mg sublingual tablets were sold in blister packs of 2 and 4 pieces. Uprima 2 mg tablets can be identified by the following signs:

  • Pentagonal shape
  • Brick-red color
  • Marking “2” on one side and ” Abbott” on the other.
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